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文章摘要
刘彦飞,王智,丁俊熊,高旭,王世范.微溶剂中硼氢化钠还原吡咯醛制备新颖吡咯醇[J].海南大学学报编辑部:自然科学版,2018,36(4):.
微溶剂中硼氢化钠还原吡咯醛制备新颖吡咯醇
Synthesis of new pyrrole alcohols using sodium borohydride reduction in small amount of PEG under grinding conditions
投稿时间:2018-06-23  修订日期:2018-07-13
DOI:
中文关键词: 硼氢化钠;聚乙二醇;还原;吡咯醛;吡咯醇;微溶剂法
英文关键词: sodium borohydride; reduction; pyrrole aldehyde; pyrrole alcohol; polyethylene glycol; solvent-small process
基金项目:海南省自然科学基金(218MS005)和海南大学重点课题(Hdcxcyxm 201712)
作者单位E-mail
刘彦飞 海南大学 海洋学院 药学系 liuyanfei0112@163.com 
王智 海南大学 海洋学院 药学系  
丁俊熊 海南大学 海洋学院 药学系  
高旭 海南大学 海洋学院 药学系  
王世范 海南大学 海洋学院 药学系 wangsf777@163.com 
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中文摘要:
      以β酮酸酯为起始原料,经亚硝化、Knorr缩合和硝酸铈铵氧化得到10个吡咯醛。然后在微量的聚乙二醇中,室温下通过研磨硼氢化钠和吡咯醛呈现面团状态,放置反应获得10个吡咯醇。全部化合物结构通过IR、1H-NMR和ESI MS表征,结果和目标化合物一致。在微溶剂中,用硼氢化钠还原吡咯醛制备吡咯醇,具有操作简单、能耗低、合成效率高、以及环境友好等优点。其中5个吡咯醛(2c, 2f, 2h-2j)和8个吡咯醇(3a-3d, 3f, 3h-3j)是首次报道的新化合物。
英文摘要:
      Ten pyrrole aldehydes were preparedSfrom β-keto acid estersSby nitrosation, Knorr condensation and oxidation with ammonium ceric nitrate. Then in the medium of micro PEG-600, the pyrrole aldehydes and sodium borohydride were grinded into the shape of dough using an agate mortar and pestle and then kept at room temperature. The corresponding alcohols were obtained. All the compounds were characterized and determined by IR, 1H NMR and ESI MS. Among them, 5 pyrrole aldehydes (2c, 2f, 2h~2j) and 8 pyrrole alcohols (3a-3d, 3f, 3h~3j) are new compounds. This synthesis method for the reduction of pyrrole aldehydes with NaBH4 has the advantage of simple operation, low energy consumption, high yield and environmental friendly.
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